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DNA-PKcs is an enzyme that in humans is encoded by the gene designated as PRKDC or XRCC7.
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This is also known as endocrine signaling.
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It is essential to nerve cell function through its mechanism of breaking down the neurotransmitter acetylcholine into its constituents, acetate and choline.
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mapk inhibitors are a chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2.
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Many drug molecules are enzyme inhibitors that inhibit an aberrant human enzyme or an enzyme critical for the survival of a pathogen such as a virus, bacterium or parasite.
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Pexidartinib inhibitor is a kinase inhibitor drug for the treatment of adults with symptomatic tenosynovial giant cell tumor.
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The structure of ritonavir, a protease inhibitor based on a peptide and containing three peptide bonds, is shown on the right.
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This reactive form of DFMO then reacts with either a cysteine or lysine residue in the active site to irreversibly inactivate the enzyme.
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If two protein kinase inhibitors both bind in the active site with similar affinity, but only one has to compete with ATP, then the competitive inhibitor at the protein-binding site will inhibit the enzyme more effectively.
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Saracatinib is an experimental drug being developed by AstraZeneca.
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Since anti-pathogen inhibitors generally target only one enzyme, such drugs are highly specific and generally produce few side effects in humans, provided that no analogous enzyme is found in humans.